AP Photo New England quarterback Tom Brady passes under pressure from Pittsburgh’s Cameron Heyward, right, in the second half Sunday. The Patriots whipped the Steelers 33-3.

JACKSONVILLE, Fla. (AP) — Despite losing star receiver Tyreek Hill early, Patrick Mahomes threw for 378 yards and three touchdowns while leading the Kansas City Chiefs to a testy and tactful 40-26 victory over the injury-riddled Jacksonville Jaguars on Sunday.

Mahomes took a beating and even had to leave the game to get his left ankle taped in the second quarter. He nonetheless looked every bit as good as he did during last year’s MVP campaign, leading the Chiefs to scores on each of their first seven possessions.

Jacksonville lost quarterback Nick Foles to a broken left clavicle.

Sammy Watkins caught nine passes for a career-high 198 yards and three TDs. Watkins slipped through the middle of Jacksonville’s defense for a 68-yard score on the third play of the season and added a 49-yard TD reception late in the opening quarter.

Mahomes picked apart what some believed is an elite defense, throwing for 313 yards in the first half and doing most of it without Hill. The three-time Pro Bowler departed after landing on his left shoulder near the sideline.

But considerably more concerning for the Jaguars, they lost Foles in the opening quarter, and rookie linebacker Quincy Williams (knee) in the second half.

Chris Jones hit Foles as he released a 35-yard TD pass to DJ Chark. Jones landed on top of Foles, but did not draw a flag. Foles looked to be in pain as he walked to the sideline to be evaluated.

PATS 33, STEELERS 3

FOXBOROUGH, Mass. (AP) — A day after the acquiring former Pittsburghs malcontent Antonio Brown, defending Super Bowl champions New England showed it might not even need him, getting 341 yards and three touchdown passes from 42-year-old Tom Brady. Phillip Dorsett caught two touchdown passes, including a 58-yard score, and Josh Gordon — another disgruntled receiver who wore out his welcome elsewhere — caught one TD pass. On the night New England unveiled its sixth NFL championship banner, Super Bowl MVP Julian Edelman caught six passes for 83 yards and also completed a throw to help the Patriots begin their quest for back-to-back titles.

TITANS 43, BROWNS 13

CLEVELAND (AP) — Marcus Mariota threw three touchdown passes — one a stunning 75-yarder to big back Derrick Henry — and the Browns fell flat on their faces in their highly anticipated opener. Titans tight end Delanie Walker had two TD catches in the fourth, and Tennessee’s defensive backs intercepted Baker Mayfield three times in the fourth period.

RAVENS 59, DOLPHINS 10

MIAMI GARDENS, Fla. (AP) –Lamar Jackson looked unstoppable from the start and tied a franchise record with five touchdown passes to help the Ravens humiliate the Dolphins and rookie coach Brian Flores. The Ravens set a franchise record for points in the first half, and an NFL record for points in the first half of an opener, taking a 42-10 lead at the break.

RAMS 30, PANTHERS 27

CHARLOTTE, N.C. (AP) — Malcolm Brown ran for a pair of scores and Jared Goff threw for 186 yards and a touchdown. Todd Gurley started and ran for 97 yards on 14 carries after being limited to 8 yards rushing on five carries in the first half.

EAGLES 32, REDSKINS 27

PHILADELPHIA (AP) — Carson Wentz threw a pair of deep touchdown passes to DeSean Jackson, and the Eagles overcame a 17-point deficit. Wentz was 28 of 39 for 313 yards and three TDs in his first game since Week 14 after not taking a snap in the preseason.

VIKINGS 28, FALCONS 12

MINNEAPOLIS (AP) — Anthony Harris highlighted a thorough thrashing by Minnesota’s defense with two interceptions of Matt Ryan and a fumble recovery. Dalvin Cook carried a revived running attack, while Eric Wilson recovered his own blocked punt at the Atlanta 21-yard line on the first possession of the game, and the Vikings were well on their way to winning a fourth straight opener. Kirk Cousins went 8 for 10 for 98 yards, all career lows for games he started, but there was no need for more.

BILLS 17, JETS 16

EAST RUTHERFORD, N.J. (AP) — Josh Allen threw a 38-yard touchdown pass to John Brown with 3 minutes left, and the Bills rallied from a 16-point second-half deficit.

BOLTS 30, COLTS 24, OT

CARSON, Calif. (AP) — Austin Ekeler scored three touchdowns, including the winner on a 7-yard run with 5:01 remaining in overtime. Philip Rivers, who made his 209th consecutive start to pass Peyton Manning for third-longest among NFL QBs, completed 25 of 34 passes for 333 yards.

SEAHAWKS 21, BENGALS 20

SEATTLE (AP) — Russell Wilson hit Tyler Lockett for a 44-yard touchdown on the first play of the fourth quarter, and the Seahawks withstood a career day from Andy Dalton.

COWBOYS 35, GIANTS 17

ARLINGTON, Texas (AP) — Dak Prescott tied his career-high with four touchdown passes while throwing for 405 yards.

49ERS 31, BUCS 17

TAMPA, Fla. (AP) — Richard Sherman and Ahkello Witherspoon returned two of a retooled San Francisco defense’s three interceptions of Jameis Winston for TDs and Robbie Gould kicked three field goals.