AP Photo NEW YORK JETS’ Jordan Jenkins takes down Dallas quarterback Dak Prescott during the second half Sunday.

EAST RUTHERFORD, N.J. (AP) — Sam Darnold gave the Jets’ struggling offense a huge boost by throwing two touchdown passes in his return from mononucleosis, and New York held on to beat Dallas 24-22 for its first win of the season.

The Jets led 21-9 in the fourth quarter, but Dak Prescott and the top-ranked Cowboys offense stormed back — and had a chance to tie in the closing moments.

Prescott ran for a 4-yard touchdown with 43 seconds left, making it a two-point game. Going for the tie, Prescott dropped back and was quickly met by a blitzing Jamal Adams and his pass on the conversion try fell short of Jason Witten in the end zone.

The Cowboys (3-3) tried an onside kick, but Demaryius Thomas recovered for the Jets (1-4), who won for the first time under coach Adam Gase. It was the third straight loss for Dallas.

Darnold, who missed three games while recovering from mononucleosis, finished 23 of 32 for 338 yards — including a 92-yard touchdown toss to Robby Anderson and a 5-yarder to Ryan Griffin.

TEXANS 31

CHIEFS 24

KANSAS CITY, Mo. (AP) — Deshaun Watson threw for 280 yards and a touchdown while running for two more, outdueling Chiefs counterpart Patrick Mahomes in a matchup of former first-round picks and leading the Houston Texans to victory.

Carlos Hyde added 116 yards rushing and a touchdown against the team that traded him to Houston (4-2) before the start of the season. DeAndre Hopkins hauled in nine passes for 55 yards.

None was bigger than his last, when the Texans star made a sliding grab on fourth-and-3 from the Kansas City 27 with just under 2 minutes to go. That allowed Houston to run out the clock and deal the Chiefs (4-2) their second consecutive loss — both at Arrowhead Stadium.

SEAHAWKS 32

BROWNS 28

CLEVELAND (AP) — Chris Carson scored on a 1-yard touchdown run with 3:30 left, Russell Wilson threw two TD passes and ran for one and Seattle rallied past mistake-prone Cleveland, improving to 3-0 on the road for the first time in 39 years. The Seahawks (5-1) gave up touchdowns on Cleveland’s first three possessions before storming back.

STEELERS 24

CHARGERS 17

CARSON, Calif. (AP) — James Conner scored two touchdowns, Devin Bush recovered a pair of turnovers and Devlin Hodges won his first NFL start as the Steelers held off the Chargers.

Conner had his first game with both a rushing and receiving touchdown and accounted for 119 scrimmage yards (41 rushing, 78 receiving).

SAINTS 13

JAGUARS 6

JACKSONVILLE, Fla. (AP) — Teddy Bridgewater found Jared Cook for a 4-yard touchdown early in the fourth quarter, and New Orleans held on to beat Jacksonville and improve to 4-0 without injured starter Drew Brees.

Coming off a 300-yard, four-touchdown performance against Tampa Bay, Bridgewater was less effective against the Jaguars (2-4). But he did enough for New Orleans’ defense.

Bridgewater was 24 of 36 passing for 240 yards for the Saints (5-1).

49ERS 20

RAMS 7

LOS ANGELES (AP) — Jimmy Garoppolo passed for 243 yards and ran for a touchdown, and San Francisco remained unbeaten with a dominant defensive performance against struggling Los Angeles.

George Kittle had eight catches for 103 yards for the Niners (5-0), who held Los Angeles’ once-unstoppable offense to 157 yards in coach Kyle Shanahan’s first victory over Rams coach Sean McVay in a game in which both of these NFC West rivals were playing their starters.

The Niners are off to their fourth 5-0 start in franchise history, and their first since 1990.

RAVENS 23

BENGALS 17

BALTIMORE (AP) — Lamar Jackson ran for a career-high 152 yards and a touchdown, threw for 236 yards and guided Baltimore past hapless Cincinnati (0-6).

Jackson carried 19 times, including three kneel-downs, and finished tantalizingly short of Michael Vick’s single-game record of 173 yards rushing by a quarterback.

Jackson now has three career 100-yard rushing games, tied with Billy Kilmer for most by a quarterback in his first two seasons since 1950.

PANTHERS 37

BUCCANEERS 26

LONDON (AP) — Christian McCaffrey scored two touchdowns and Carolina turned five interceptions by Jameis Winston into 17 points as the Panthers beat Tampa Bay.

After starting the season with two straight losses with hobbled Cam Newton at quarterback, the Panthers (4-2) have been on a roll with Kyle Allen at quarterback thanks to McCaffrey’s big plays and an opportunistic defense that had a franchise record-tying seven takeaways on the day.

REDSKINS 17

DOLPHINS 16

MIAMI GARDENS, Fla. (AP) — Rookie Terry McLaurin caught two touchdown passes and Washington stopped Miami’s two-point conversion attempt with 6 seconds left in a matchup between winless teams.

BRONCOS 16

TITANS 0

DENVER (AP) — Denver’s swarming defense sent Marcus Mariota to the bench and Tennessee to its fourth loss in five games.

The Broncos (2-4) had seven sacks in a game for the first time since their 2015 Super Bowl season and they picked off three passes.

CARDINALS 34

FALCONS 33

GLENDALE, Ariz. (AP) — Kyler Murray threw for 340 yards and three touchdowns and Arizona built a big lead over Atlanta, lost it, and then rallied to win.

Atlanta looked like it would tie the game with 1:53 left after Matt Ryan hit Devonta Freeman on a 12-yard touchdown pass, but 44-year-old Matt Bryant missed left on the extra point, and the Cardinals ran out the clock from there.