Detroit Lions quarterback Jared Goff (16) is introduced before an NFL football game against the Chicago Bears, Thursday, Nov. 28, 2024, in Detroit. (AP Photo/Carlos Osorio)

The Detroit Lions are hosting the Buffalo Bills in what’s potentially a Super Bowl preview.

The Lions are the odds-on favorite to win the NFL title, according to BetMGM. The Bills are among the top contenders.

Detroit is favored by 2 1/2 points at home on Sunday. The game features MVP candidates: Buffalo’s Josh Allen and Detroit’s Jared Goff.

Buffalo’s passing game against Detroit’s secondary may prove to be pivotal. Allen has been nearly unstoppable and the Lions have struggled to stop many teams from gaining a lot of yards.

Buffalo (10-3) at Detroit (12-1), Sunday, 3:25 p.m. CBS

Series record: Bills lead 7-4-1.

Last meeting: Bills beat Lions 28-25 on Nov. 24, 2022, in Detroit.

Last week: Bills lost to Rams 44-42; Lions beat Packers 34-31.

Bills offense: overall (10), rush (11), pass (12), scoring (2).

Bills defense: overall (14), rush (19), pass (9), scoring (8).

Lions offense: overall (2), rush (4), pass (4), scoring (1).

Lions defense: overall (10), rush (5), pass (23), scoring (T-2).

Turnover differential: Bills plus-17; Lions plus-8

Bills player to watch

Josh Allen. In his seventh season, he’s making a strong case to be NFL MVP with 10 TDs in the past two games. Last week, Allen became the league’s first player to throw three TD passes and score three times rushing. Two weeks ago, he became the NFL’s first quarterback to be credited with two scores on one play — a TD passing and one receiving — in completing a pass to Amari Cooper and scoring when the WR tossed the ball back to the QB.

Lions player to watch

Jared Goff. With a banged-up defense, the Lions are going to have to keep up with the Allen-led Bills. Goff has completed 72.4% of his passes, ranking second in the NFL. If he completes three-fourths of his passes in one more game, he will join Tom Brady (2007) as the only players in league history to connect on 75% of passes in eight or more games. In Detroit’s past five home games, Goff has thrown 14 TDs and only one INT since throwing two INTs without a TD in the team’s only loss to Tampa Bay in Week 2.

Key matchup

Buffalo’s passing game against Detroit’s secondary. Allen has been nearly unstoppable and the Lions have struggled to stop many teams from gaining a lot of yards with passes and penalties for pass interference.

Key injuries

Bills CB Rasul Douglas (knee) S Taylor Rapp (shoulder, neck) did not practice Wednesday or Thursday. TE Dalton Kincaid, who has missed three games with a knee injury, and WR Keon Coleman, who’s missed four games with an injured right wrist, are in position to return this week. … Lions DT D.J. Reader (shoulder) was limited in practice Thursday after missing the previous game. … OT Taylor Decker (knee) and DT Alim McNeill (concussion) practiced in full on Wednesday and Thursday, moving closer to playing. … DL Levi Onwuzurike (hamstring) was limited in practice Thursday and DL Josh Paschal (knee) was a full participant. … LB Trevor Nowaske (concussion) was held out of practice Thursday.

Series notes

The Bills have won six of the past seven meetings, losing only in 2006 in Detroit. … Tyler Bass made a tiebreaking 45-yard field goal with 2 seconds left after missing an extra point late in the fourth quarter to give Buffalo a 28-25 win against the Lions on Thanksgiving two years ago. It was the Bills’ second win at Ford Field in five days, following their victory against Cleveland after a winter storm dumped several feet of snow in western New York and shifted the game to the Motor City.

Stats and stuff

Despite losing to the Rams to end a seven-game winning streak, the Bills are 10-3 or better through 13 games for the third time since 2020 and the eighth time in team history. … The Bills have set a franchise record with an active run of scoring 30-plus points to seven straight games. … Allen had his seventh turnover-free outing last week and his career record dropped to 30-6 when not throwing an interception or losing a fumble. He is 43-27 when committing a turnover, including a 5-1 mark this season.

The Bills’ run of 14 straight games — 16 including playoffs — with a takeaway, going back to last season, ended last week.

The Lions are aiming to extend their franchise-record winning streak to 12 games. … Detroit has earned a postseason bid in consecutive seasons for the first time since a three-year run from 1993 through the 1995 season.

David Montgomery and Jahmyr Gibbs are the first NFL teammates to have 2,000-plus yards from scrimmage and 20 TDs in their first 25 games together. … WR Amon-Ra St. Brown is tied for second with nine receiving TDs and tied for third with 81 catches. … DE Za’Darius Smith has a sack against the Bills in his past two games against them.