BOSTON (AP) — Five Houston players homered off Boston’s Nathan Eovaldi in the second inning, tying a major league record as the Astros beat the Red Sox 13-4 on Tuesday night.

Yordan Alvarez, Kyle Tucker, Jeremy Pena, Michael Brantley and Yuli Gurriel all went deep for the Astros, who set a franchise mark for home runs in an inning. It has happened seven other times in the majors.

Tucker added his second homer of the night and seventh of the season in the fourth inning — a grand slam off Tyler Danish — as Houston won for the 13th time in 15 games.

Jose Urquidy (3-1) allowed 12 hits and four runs, including home runs to Rafael Devers and J.D. Martinez, but lasted five innings.

Eovaldi (1-2) became the third pitcher in major league history to surrender five homers in an inning. His line: 1 2/3 innings, eight hits, nine runs (six earned) and five home runs over 39 pitches.

YANKEES 5, ORIOLES 4

BALTIMORE (AP) — Aaron Judge homered twice after his first-inning drive bounced off the new left-field wall at Camden Yards, and New York held off Baltimore for its 20th win in 23 games.

Judge came within a few feet of a three-homer game. His bid in the first hit high off the wall — which was moved back and made taller before this season. He settled for an RBI double, then hit solo shots in the third and fifth to increase his major league-leading home run total to 14.

Judge added a single in the eighth for his third four-hit game and first since 2019.

Ramon Urias went deep for the Orioles, who have lost five straight and matched their season high. Aroldis Chapman allowed a run in the ninth before finishing his ninth save in nine chances.

Jameson Taillon (4-1) allowed three runs in five-plus innings. Reliever Dillon Tate (0-2) took the loss.

CUBS 7, PIRATES 0

CHICAGO (AP) — Keegan Thompson combined with three relievers on a five-hitter, and Chicago shut out Pittsburgh for the second straight game while extending its winning streak to a season-best four.

Jonathan Villar hit a go-ahead, solo homer in the third and added an RBI single.

Thompson (3-0) allowed four hits and four walks in five innings, while striking out five in his second start this season.

JT Brubaker (0-4) gave up six runs — four earned — and six hits in six innings while striking out a career-high 10.

DODGERS 7, DIAMONDBACKS 6 (GAME 1)

LOS ANGELES (AP) — Mookie Betts, Trea Turner and Justin Turner homered in a five-run sixth inning, and Los Angeles outlasted Arizona to begin the first doubleheader ever played by the NL West rivals.

Will Smith also connected early for the Dodgers, whose four homers matched their season high.

Christian Walker hit an early two-run homer and Alek Thomas added a solo shot in the seventh for the Diamondbacks, who lost their fourth straight in the opener of Dodger Stadium’s first doubleheader since 1999.

The Dodgers fell behind before their sluggers got to Tyler Gilbert (0-2) in the sixth.

Ryan Pepiot gave up three runs and two hits over four innings for Los Angeles in his second big league start. Five relievers then combined for five innings of four-hit ball, with Justin Bruihl (1-1) getting the win.

BLUE JAYS 3, MARINERS 0

TORONTO (AP) — Jose Berrios and two relievers combined on a six-hitter, George Springer provided all the offense with a bases-loaded triple, and Toronto beat Seattle

Berrios (3-2) stopped a two-start losing streak and matched his season high of seven innings. The right-hander allowed six hits, walked two and struck out four.

David Phelps worked the eighth and Adam Cimber finished for his third save in five chances as the Blue Jays won back-to-back games for the first time since victories over Houston on April 30 and May 1.

Logan Gilbert (4-2) allowed three runs and six hits in a season-high seven innings.

METS 3, CARDINALS 1 (GAME 1)

NEW YORK (AP) — Jeff McNeil and Dominic Smith helped chip away at Miles Mikolas, Trevor Williams was sharp in a spot start and New York beat St. Louis to open a doubleheader.

McNeil and Smith each had two hits, including an RBI double apiece in the third inning.

Mikolas (3-2) allowed a season-high three runs (two earned) over six innings.

Williams threw four scoreless innings in a spot start for injured Tylor Megill. Jake Reed (1-0) followed Williams with two scoreless innings in his 2022 debut.

St. Louis put two runners on against Edwin Diaz in the ninth, but the Mets closer struck out Harrison Bader swinging to end his ninth save.

CARDINALS 4, METS 3 (GAME 2)

NEW YORK (AP) — Tyler O’Neill redeemed himself after setting a St. Louis record for a doubleheader with six strikeouts, beating out a tiebreaking infield single in the ninth inning for a split against New York.

After the Mets tied it in the eighth, St. Louis drew two walks against Joely Rodriguez (0-2) in the ninth. O’Neill hit a weak roller off Adam Ottavino. Sure-handed third baseman Eduardo Escobar charged hard but double clutched at the ball, allowing the speedy O’Neill to reach first while Brendan Donovan scored from third.

Giovanny Gallegos allowed one-out singles to Dominic Smith and Luis Guillorme in the ninth, then struck out Mark Canha and Francisco Lindor for his seventh save.

Jeff McNeil tied the game against Ryan Helsley (2-0) after the eighth inning was extended by a dropped third strike.

WHITE SOX 3, ROYALS 0, GAME 1

KANSAS CITY, Mo. (AP) — Jose Abreu hit a two-run double in a three-run fifth inning, Dylan Cease pitched scoreless ball into the sixth, and Chicago beat Kansas City in the opener of a doubleheader.

Cease (4-1) gave up seven hits in 5 2/3 innings, with nine strikeouts — several in clutch situations.

Liam Hendriks worked the ninth for his 11th save in 14 opportunities.

The Royals struck out 14 times overall, went 0-for-12 with runners in scoring position and stranded 12 runners.

Jonathan Heasley (0-2) pitched around trouble until his final inning, the fifth.

ROYALS 2, WHITE SOX 1, GAME 2

KANSAS CITY, Mo. (AP) — Brady Singer pitched seven scoreless innings to outduel Davis Martin, and Kansas City split a doubleheader with Chicago.

M.J. Melendez hit his first career homer for the Royals.

Singer (1-0) struck out a career-high nine batters, allowed four hits and didn’t walk anyone.

Martin (0-1) allowed one run on five hits in five innings.

Josh Staumont earned his third save in five chances.

PADRES 3, PHILLIES 0

PHILADELPHIA (AP) — Mike Clevinger tossed one-hit ball over five shutout innings and combined with two relievers to lead San Diego past Philadelphia.

Clevinger (1-0) won for the first time in three starts this season. The righty tossed five innings for the first time this year, striking out five and walking none over 75 pitches.

MacKenzie Gore struck out four in three scoreless innings and Taylor Rogers worked the ninth for his 14th save.

Zach Eflin (1-3) nearly matched Clevinger with five strikeouts over six innings. He gave up a run in the fifth on a forceout.

REDS 5, GUARDIANS 4 (10 INNINGS)

CLEVELAND (AP) — Mike Moustakas drew the third straight walk in the 10th inning by Nick Sandlin to force in a run, and Cincinnati held on to beat Cleveland.

Moustakas took three straight pitches from Sandlin (3-2) to bring in Matt Reynolds, who started the inning at second base.

Art Warren (2-1) gave up Owen Miller’s tying, two-run homer in the ninth. Rookie reliever Alexis Diaz struck out Cleveland star Jose Ramirez with the bases loaded for the final out and his first save.

MARLINS 5, NATIONALS 1

MIAMI (AP) — Miguel Rojas homered, doubled and singled to lead Miami past Washington.

Jesus Sanchez also went deep and Jesus Aguilar had two hits for the Marlins, who will attempt to complete their second three-game sweep of the season against Washington on Wednesday.

Miami starter Cody Poteet pitched 4 2/3 scoreless innings in his first start of the season. Anthony Bender (1-3) relieved Poteet and threw one scoreless inning. Four additional Miami relievers combined to get the final 13 outs.

Joan Adon (1-7) allowed one run, five hits, struck out two and hit a batter with a pitch in 4 2/3 innings.