Joe Flacco talks after a win against against the Green Bay Packers on Sept. 21 in Cleveland. (AP Photo/Sue Ogrocki)

A Lions-Chiefs matchup was considered a potential Super Bowl preview when the schedule came out.

It still could be considering the state of the AFC.

Jared Goff leads a dynamic Lions offense against Patrick Mahomes and the inconsistent Chiefs on Sunday night in Kansas City in one of the biggest games in Week 6.

Detroit (4-1) rebounded from a lopsided loss to Green Bay in Week 1 to win four in a row. The Chiefs (2-3) were on the right track with two straight wins after opening 0-2 but gave up a final-minute score to lose to Jacksonville on Monday night.

Still, Kansas City is only one game behind in the AFC West and two behind the Bills (4-1), Jaguars (4-1) and Colts (4-1). The Chiefs visit Buffalo in Week 9 so they just need to go on a run.

The Lions are 12-2 in prime-time games with Goff and coach Dan Campbell but both of those losses came as underdogs.

Despite owning a losing record, the Chiefs are 2 1/2-point favorites, according to BetMGM Sportsbook.

Pro Picks leans toward the home team.

CHIEFS: 30-27

NEW ENGLAND (3-2) at NEW ORLEANS (1-4)

Line: Patriots minus 3 1/2

Drake Maye and the Patriots made a statement with a comeback win at Buffalo.

BEST BET: PATRIOTS: 26-17

SEATTLE (3-2) at JACKSONVILLE (4-1)

Line: Jaguars minus 1

The Seahawks nearly overcame an injury-depleted defense before a late pick by Sam Darnold led to a loss. Despite the turnover, Darnold is thriving in Seattle’s offense.

UPSET SPECIAL: SEAHAWKS: 27-23

DENVER (3-2) at NEW YORK JETS (0-5), in London

Line: Broncos minus 7 1/2

Bo Nix and the Broncos overcame a 14-point, fourth-quarter deficit in Philadelphia to hand the Eagles their first loss.

BRONCOS: 24-13

LOS ANGELES RAMS (3-2) at BALTIMORE (1-4)

Line: Rams minus 7 1/2

The Rams let an injury-riddled 49ers team missing Brock Purdy and several more key starters beat them at home. They’ll have to be ready for another team decimated by injuries.

RAMS: 26-20

LOS ANGELES CHARGERS (3-2) at MIAMI (1-4)

Line: Chargers minus 4 1/2

A depleted offensive line has impacted Justin Herbert and now he won’t have running back Omarion Hampton for four games and Najee Harris is already out for the season.

CHARGERS: 23-20

CLEVELAND (1-4) at PITTSBURGH (3-1)

Line: Steelers minus 5

Rookie Dillon Gabriel played well in his first career start despite a loss to Minnesota in London.

STEELERS: 20-17

DALLAS (2-2-1) at CAROLINA (2-3)

Line: Cowboys minus 3 1/2

Dak Prescott is playing at an MVP level, helping the Cowboys stay competitive despite a dismal defense.

COWBOYS: 27-20

ARIZONA (2-3) at INDIANAPOLIS (4-1)

Line: Colts minus 6 1/2

Daniel Jones, Jonathan Taylor and rookie tight end Tyler Warren have the Colts off to an excellent start.

COLTS: 27-20

TENNESSEE (1-4) at LAS VEGAS (1-4)

Line: Raiders minus 4 1/2

Cam Ward called out his team and then led the Titans to their first win.

RAIDERS: 26-19

CINCINNATI (2-3) at GREEN BAY (2-1-1)

Line: Packers minus 14

Joe Flacco beat the Packers last month with the Browns. Now, he gets a shot to do it again just five days after joining the Bengals. The Packers followed up a loss to the Browns with a disappointing tie against Dallas. Micah Parsons could have a career day chasing the 40-year-old Flacco.

PACKERS: 31-13

SAN FRANCISCO (4-1) at TAMPA BAY (4-1)

Line: Buccaneers minus 3

Mac Jones led the depleted 49ers to an improbable Thursday night win against the Rams and is 3-0 as a starter.

BUCCANEERS: 27-23

BUFFALO (4-1) at ATLANTA (2-2)

Line: Bills minus 4 1/2

Josh Allen and the Bills try to rebound after their first loss of the season.

BILLS: 24-20

CHICAGO (2-2) at WASHINGTON (3-2)

Line: Commanders minus 4 1/2

The Bears’ 10-game losing streak last season began when Jayden Daniels and the Commanders beat them on a Hail Mary pass. Chicago has a better team this time around. Daniels returned after missing two games and led Washington to a convincing win on the road against the Chargers. Daniels is 4-2 in prime-time games. Williams is 0-4.

COMMANDERS: 27-20

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Last week: Straight up: 8-6. Against spread: 8-6.

Overall: Straight up: 55-22-1. Against spread: 40-38.