Detroit Lions middle linebacker Alex Anzalone (34) against the Cleveland Browns on Sunday in Detroit. (AP Photo/Rey Del Rio)

The Philadelphia Eagles keep finding ways to win. The Denver Broncos are aiming to hand them that first loss.

Coming off a lopsided rout over Cincinnati on Monday night, the Broncos (2-2) have a tough challenge with a short turnaround going to face the reigning Super Bowl champs.

The Eagles (4-0) needed a last-second blocked field goal to beat the Rams, and a blocked punt that was returned for a score helped them defeat the Buccaneers

The Eagles are 3 1/2-point favorites, according to BetMGM Sportsbook. Pro Picks sees a close one.

EAGLES: 24-23

Houston (1-3) at Baltimore (1-3)

Line: Texans minus 1

C.J. Stroud and the Texans saved their season last week. If Lamar Jackson can’t play, it’ll be Cooper Rush starting for Baltimore.

BEST BET: TEXANS: 23-17

Miami (1-3) at Carolina (1-3)

Line: Dolphins minus 1 1/2

Tua Tagovailoa and the Dolphins got their first win but lost Tyreek Hill in the process.

UPSET SPECIAL: PANTHERS: 23-20

Minnesota (2-2) vs. Cleveland (1-3), in London.

Line: Vikings minus 3 1/2

Carson Wentz got pummeled by the Steelers last week and needs to get rid of the ball faster with a depleted line and Myles Garrett coming after him.

VIKINGS: 22-20

Las Vegas (1-3) at Indianapolis (3-1)

Line: Colts minus 7

Geno Smith has to stop throwing the ball to the other team to give the Raiders a chance.

COLTS: 24-19

New York Giants (1-3) at New Orleans (0-4)

Line: Saints minus 2

Losing Malik Nabers for the season dampened Jaxson Dart’s winning debut for the Giants.

SAINTS: 20-16

Dallas (1-2-1) at New York Jets (0-4)

Line: Cowboys minus 2 1/2

Not losing to Micah Parsons and the Packers was a win for Dallas, even though nobody likes a tie. Dak Prescott is playing at an MVP level.

COWBOYS: 26-22

Tennessee (0-4) at Arizona (2-2)

Line: Cardinals minus 7 1/2

Cam Ward and Jeffery Simmons are frustrated with losing, coach Brian Callahan is under intense scrutiny and the Titans have looked terrible.

CARDINALS: 23-13

Tampa Bay (3-1) at Seattle (3-1)

Line: Seahawks minus 3 1/2

The injury-riddled Buccaneers could’ve upset Philly if special teams didn’t give up another TD.

SEAHAWKS: 24-20

Detroit (3-1) at Cincinnati (2-2)

Line: Lions minus 10 1/2

Dan Campbell’s Lions are looking like the team that won 15 games last season. They do have some injury concerns in the secondary, though. The Bengals didn’t show up Monday night in Denver. Zac Taylor needs to figure things out. Losing Joe Burrow is no excuse for no-showing.

Washington (2-2) at Los Angeles Chargers (3-1)

Line: Chargers minus 2 1/2

Jayden Daniels was cleared to return from a knee injury that sidelined him two games.

COMMANDERS: 23-22

New England (2-2) at Buffalo (4-0)

Line: Bills minus 8

Drake Maye is playing up to expectations and Stefon Diggs’ addition has helped New England.

BILLS: 27-20

Kansas City (2-2) at Jacksonville (3-1)

Line: Chiefs minus 3 1/2

Xavier Worthy’s return has sparked Patrick Mahomes and the Chiefs, who opened 0-2.

CHIEFS: 24-17

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Last week: Straight up: 11-4-1. Against spread: 8-8.

Overall: Straight up: 47-16-1. Against spread: 32-32.

Prime-time: Straight up: 10-4-1. Against spread: 6-9.

Best Bet: Straight up: 3-1. Against spread: 2-2.

Upset Special: Straight up: 3-1. Against spread: 3-1.