Detroit Tigers relief pitcher Michael Fulmer, left, waits for Cleveland Indians' Franmil Reyes, right, to run the bases on a solo home run during the sixth inning in a baseball game Friday, April 9, 2021, in Cleveland. (AP Photo/Tony Dejak)

CLEVELAND (AP) — Franmil Reyes homered twice and Zach Plesac pitched seven dominant innings after getting an early lead to give the Cleveland Indians a 4-1 win Friday night over the Detroit Tigers, who scratched starter Julio Teheran just before the first pitch.

Reyes hit a two-run homer in the first off emergency starter Derek Holland (0-1) and added a 446-foot solo shot in the sixth to make it 4-0.

For the second straight game, one player carried the Indians offense. José Ramirez homered twice on Wednesday in a 4-2 win over Kansas City.

“When those hits start dropping, we’re going to be good,” Reyes said. “Hopefully we get more games like this where we take the lead earlier.”

Plesac (1-1) pitched scoreless ball, allowing just three singles while improving to 3-1 in five career starts against the Tigers. He has surrendered three earned runs in 30 2/3 innings against Detroit.

“He filled up the strike zone the entire night,” Indians manager Terry Francona said. “The fastball, I don’t know what it said on the gun, but it had a lot of life to it.”

The Tigers avoided being shut out when Wilson Ramos homered off Bryan Shaw in the eighth.

Emmanuel Clase worked the ninth — breaking 100 mph on most of his 14 pitches — for his first save with Cleveland and the second of his career. He got one with Texas in 2019.

Detroit was forced to make the pregame pitching change after Teheran complained of tightness in his right triceps at the end of his warmup. He beat the Indians in his debut for the Tigers last week, allowing one run and four hits in five innings.

Teheran told pitching coach Chris Fetter about the discomfort, and Fetter called manager A.J. Hinch just as his relievers were heading to the bullpen in Progressive Field.

“He was willing to pitch,” Hinch said. “But it wasn’t looking good from what Fett told me, and there’s no need to risk further injury, so got Holland up and running.”

Hinch didn’t know if Teheran will miss extended time.

“You pull a pitcher right before the start of the game, it doesn’t feel good,” Hinch said. “It doesn’t look good. I’m not sure whether or not he’s going to be able to avoid any injury-list time or anything like that.”

Hinch used Michael Fulmer for four innings (68 pitches), so he is stretched out in case he has to take Teheran’s rotation spot.

Reyes’ 409-foot liner into the left-field bleachers gave the Indians a 3-0 lead in the first, which began with the announcement that Teheran wouldn’t be pitching.

In the sixth, Reyes ripped a 2-2 pitch from Fulmer over the wall in center and into some still blooming trees inside Heritage Park.

“I’m glad I don’t chew anymore because I probably would have swallowed my chew,” Francona joked. “You know what, he doesn’t back down, man. He’s going to be OK. Is it going to be perfect? I don’t know. But he might just be OK.”