Tampa Bay QB Tom Brady (12) passes against Saints in New Orleans on Sunday. (AP Photo)

Tom Brady was intercepted twice in his Tampa Bay debut, Alvin Kamara scored touchdowns running and receiving, and the New Orleans Saints beat the Buccaneers 34-23 on Sunday.

The first of Brady’s interceptions led to Kamara’s 6-yard touchdown run. The second pick thrown by the new, 43-year-old Bucs QB — who left the New England Patriots in free agency after 20 years and six Super Bowl triumphs — was returned 36 yards for a touchdown by Janoris Jenkins.

Neither quarterback was statistically exceptional in this first-ever NFL game featuring two quarterbacks in their 40s. The 41-year-old Drew Brees passed for 160 yards and two TDs, but he also avoided critical mistakes. He did not turn over the ball and took only one sack. His first TD pass was a dump-off to Kamara from 12 yards. In the fourth quarter he hit free-agent signing Emmanuel Sanders for a 5-yard score.

Few witnessed this historically significant quarterback matchup in person, with government leaders and the Saints having agreed that no fans should attend the opener amid the coronavirus pandemic. That turned the normally deafening 73,000-seat Superdome into more of an echo chamber. When Wil Lutz’s field goal put New Orleans up 17-7, the squeaking of pulleys could be heard across the stadium as the net behind the goal post was lowered.

CARDINALS 24. 49ERS 20

SANTA CLARA, Calif. (AP) — DeAndre Hopkins had a career-high 14 catches for 151 yards in his Arizona debut and set up Kenyan Drake’s 1-yard TD run with 5:03 to play.

CHARGERS 16

BENGALS 13

CINCINNATI (AP) — Heisman Trophy winner Joe Burrow ran 23 yards untouched for a touchdown — the best moment of his NFL debut — but the Chargers roughed him up and rallied.

WASHINGTON 27

EAGLES 17

LANDOVER, Md. (AP) — Peyton Barber ran for two touchdowns and Dwayne Haskins rallied Washington from a 17-point deficit.

RAVENS 38, BROWNS 6

BALTIMORE (AP) — Looking every bit like the reigning NFL MVP, Lamar Jackson threw for 275 yards and three touchdowns, ruining Kevin Stefanski’s debut as Cleveland’s head coach.

PATS 21, DOLPHINS 11

FOXBOROUGH, Mass. (AP) — Cam Newton looked just fine as Tom Brady’s replacement, rushing for two touchdowns.

SEAHAWKS 38

FALCONS 25

ATLANTA (AP) — Russell Wilson was cooking right from the start, throwing four touchdown passes. He completed 31 of 35 passes for 322 yards, throwing a pair of TD passes in the first quarter.

JAGUARS 27, COLTS 20

JACKSONVILLE, Fla. (AP) — Gardner Minshew threw three touchdown passes, including a 22-yarder to Keelan Cole in the fourth quarter, and Jacksonville stunned Indianapolis and Philip Rivers.

RAIDERS 34

PANTHERS 30

CHARLOTTE, N.C. (AP) — Josh Jacobs ran for 93 yards and three touchdowns, Derek Carr threw for 239 yards and a score to spoil Matt Rhule’s coaching debut.

BILLS 27, JETS 17

ORCHARD PARK, N.Y. (AP)– Josh Allen led three consecutive first-half touchdown drives, and the Bills overcame their own sloppiness and injuries to two starting linebackers.